BackgroundPseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
DescriptionPhospho-MLKL (S358) Recombinant Monoclonal Antibody [4A6]. Unconjugated. Raised in: HEK293F Cell.
FormulationRabbit IgG in 10mM phosphate buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA*, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ8NB16
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-MLKL (S358)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMixed lineage kinase domain-like protein, hMLKL, MLKL
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200
*The BSA is derived from animal or animal-derived material of negligible amounts. The animal-derived material is subject to heat treatment at a temperature higher than 65°C for at least three hours and acid treatment with pH value of less than 5 for at least three hours, thereby being free of Bovine Spongiform Encephalopathy (BSE) and Transmissible Spongiform Encephalopathy (TSE). Additionally, as all BSA-containing products are strictly intended for research purposes and not for diagnostic or therapeutic use, they are not subject to certification authority oversight.
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