BackgroundThis gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
DescriptionOGG1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDO15527
PurificationAffinity Purification
ImmunogenA synthetic peptide of human OGG1
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesOGG1; HMMH; HOGG1; MUTM; OGH1; N-glycosylase/DNA lyase
ApplicationWB; Recommended dilution: WB 1:200 - 1:1000
Cart (0)
