Background8-Oxoguanine glycosylase (OGG1) is an enzyme responsible for the removal of 8-oxoguanine (8-oxoG), a mutagenic base byproduct that emerges as a result of reactive oxygen species (ROS) exposure. The action of OGG1 involves lyase activity for chain cleavage. Two major groups of alternative splice variants exist for this gene. Type 1 variants end with exon 7 and type 2 variants end with exon 8. The N-terminal region for all variants is the same. This region contains a mitochondrial targeting signal that is necessary for mitochondrial localization. Several alternative splice variants for OGG1 have been identified, yet the nature of every variant is not fully understood.
DescriptionOGG1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Formulation Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1).
IsotypeIgG
Uniprot IDO15527
PurificationAffinity Purified
StorageShipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Alternative NamesHMMH, MUTM, OGH1, HOGG1
ApplicationWB, IHC; Recommended dilution: WB 1:500 - 1:2000, IHC 1:50 - 1:200
