BackgroundReceptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
DescriptionILK Recombinant Monoclonal Antibody [6A5]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse
IsotypeRabbit IgG
Uniprot IDQ13418
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human ILK
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesIntegrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK), ILK, ILK1 ILK2
ApplicationELISA, WB, IF, IP; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200, IP:1:200-1:1000