BackgroundInterferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
DescriptionIFIT5 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Formulation0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4
SpecificityHuman
IsotypeIgG
Uniprot IDQ13325
PurificationProtein G purified
ImmunogenRecombinant Human Interferon-induced protein with tetratricopeptide repeats 5 protein (107-320AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesInterferon-induced protein with tetratricopeptide repeats 5, IFIT-5, IFIT5, ISG58, RI58, Interferon-induced 58 kDa protein, Retinoic acid- and interferon-inducible 58 kDa protein, P58
ApplicationELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200