BackgroundInterferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.
DescriptionIFIT5 Polyclonal Antibody, HRP Conjugated. HRP. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDQ13325
Purification>95%, Protein G purified
ImmunogenRecombinant Human Interferon-induced protein with tetratricopeptide repeats 5 protein (107-320AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesInterferon-induced protein with tetratricopeptide repeats 5, IFIT-5, IFIT5, ISG58, RI58, Interferon-induced 58 kDa protein, Retinoic acid- and interferon-inducible 58 kDa protein, P58
ApplicationELISA; Recommended dilution: ELISA 1:500-1:1000