BackgroundMitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
DescriptionHMGCL Recombinant Monoclonal Antibody [22H11]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP35914
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human HMGCL
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesHydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase), HMGCL
ApplicationELISA, WB, IHC, FC; Recommended dilution: WB:1:500-1:2000, IHC:1:50-1:200, FC:1:50-1:200
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