HMBS Recombinant Monoclonal Antibody [8G12]

Background
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.

Description
HMBS Recombinant Monoclonal Antibody [8G12]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
Rabbit IgG

Uniprot ID
P08397

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human HMBS

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
Porphobilinogen deaminase (PBG-D) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase), HMBS, PBGD UPS

Application
ELISA, WB; Recommended dilution: WB:1:500-1:2000