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FZR1 Polyclonal Antibody

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Western blot
All Lanes: FZR1 Antibody at 6ug/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 55 kDa
Observed band size: 55 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using FZR1 Polyclonal Antibody at dilution of 1:100
Application: ELISA, IHC, WB
Areas of Research: Cell Cycle
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
100% Guarantee: 6 months
Catalog No.SizePriceQty
A51405-02020 µg $99.00 
A51405-05050 µg $256.00 
A51405-100100 µg $359.00 
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Product Overview

Background
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Description
FZR1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
Q9UM11

Purification
Protein G purified

Immunogen
Recombinant Human Fizzy-related protein homolog protein (1-493AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Fzr, CDC20-like protein 1, hCDH1, Cdh1/Hct1 homolog, CDH1, FYR, FZR, KIAA1242, FZR1

Application
ELISA, WB, IHC; Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

User Guide & MSDS

[User Guide]*
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