BackgroundDNA methylation and demethylation are major epigenetic mechanisms that modulate gene expression in both eukaryotes and prokaryotes. Epigenetic modification 5-methylcytosine (5mC), considered the hallmark of gene silencing, has been implicated to play an important role in regulating several cellular and developmental processes, including mediating carcinogenic transformation of healthy cells. 5-hydroxymethylcytosine (5hmC) derived from enzymatic oxidization of 5mC has also been associated with many biological processes, including the pluripotency of embryonic stem cells, neuron development, and tumorigenesis in mammals.
DescriptionEpiGentek's Antibody Panel Packs provide a convenient way to investigate a panel of modifications using a collection of select antibodies. The DNA Methylation Antibody Panel Pack I is a complete set of 2 vials for the investigation of both 5-mC and 5-hmC, plus a bonus vial of secondary antibody is also included:
StorageVaries. Please see user guide for recommended storage conditions for each antibody.