BackgroundComponent of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
DescriptionRQCD1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Formulation0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDQ92600
PurificationProtein G purified
ImmunogenRecombinant Human CCR4-NOT transcription complex subunit 9 protein (1-258AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesCell differentiation protein RCD1 homolog, Rcd-1, RQCD1, CNOT9, RCD1, CCR4-NOT transcription complex subunit 9
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200