BackgroundResponsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
DescriptionQPCT Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman, Rat
IsotypeIgG
Uniprot IDQ16769
PurificationProtein G purified
ImmunogenRecombinant Human Glutaminyl-peptide cyclotransferase protein (29-361AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesGlutaminyl cyclase Glutaminyl-tRNA cyclotransferase Glutamyl cyclase QPCT
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200