BackgroundPRMT7, or Protein Arginine N-Methyltransferase 7, part of the PRMT family of proteins, can catalyze the formation of symmetrical dimethylarginine (sDMA) but has a preference for forming omega-N monomethylarginine (MMA). In SNRPD1 (small nuclear ribonucleoprotein Sm D1) and SNRPD3 (small nuclear ribonucleoprotein Sm D3), PRMT7 mediates the symmetrical dimethylation of these arginine residues. This dimethylation is necessary for the biogenesis and assembly of snRNP core particles. Specifically, PRMT7 form H4R3me2s via mediation of symmetric dimethylation of Histone H4 Arg3. PRMT7 is also thought to play a role in gene imprinting, recruiting DNA methyltransferases as various sites, and embryonic stem cell (ESC) pluripotency.
DescriptionPRMT7 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3..
SpecificityHuman, Mouse, Rat
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 513-692 of human PRMT7 (NP_061896.1).
IsotypeIgG
Uniprot IDQ9NVM4
PurificationAffinity Purified
StorageShipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Alternative Names[Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody, ANM7_HUMAN antibody, FLJ10640 antibody, Histone-arginine N-methyltransferase PRMT7 antibody, KIAA1933 antibody, OTTHUMP00000174863 antibody, PRMT7 antibody, Protein arginine N-methyltransferase 7 antibody
ApplicationWB
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