BackgroundThis serine/threonine kinase is a vital component of the MAP kinase signaling pathway. MAPK1/ERK2 and MAPK3/ERK1 are two key players within this pathway, crucial for a range of functions including cell growth, adhesion, survival, differentiation, and the regulation of transcription and translation. The cascade also influences processes such as meiosis, mitosis, and apoptosis by phosphorylating various transcription factors and other substrates. ERKs have around 160 substrates discovered so far, which are involved in nuclear, cytoplasmic, and organelle-related activities. These substrates encompass transcription factors, cytoskeletal elements, apoptosis regulators, translation regulators, and diverse signaling molecules. The cascade additionally impacts endosomal dynamics and Golgi fragmentation. The propagation of the MAPK/ERK signal extends to various kinases and phosphatases, expanding the cascade's specificity.
DescriptionPhospho-MAPK3 (T202)/MAPK1 (T185) Recombinant Monoclonal Antibody [2D5]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP27361
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-MAPK3 (T202) + MAPK1 (T185)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERT2, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, p44-MAPK, Microtubule-associated protein 2 kinase, p44-ERK1, MAPK3, ERK1, PRKM3
ApplicationELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200
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