BackgroundHistone lysine lactation (Kla) is a newly discovered histone modification that regulates gene expression in macrophages. In M1 macrophages, lactic acid is derived from incompletely oxidized glucose and then produces lactyl-CoA, which is transferred via acetyltransferase p300 to the lysine tail of the histone. This modification is abundant in gene promoter regions that lack acetylation and are associated with gene expression activation.
DescriptionPan Lactic acid-Lysine Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.09% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat, Other (Broad Range)
IsotypeIgG
PurificationAffinity Purified
ImmunogenSynthetic peptide. Please contact EpigenTek for more information.
StorageStore at -20°C. Avoid freeze / thaw cycles.
Alternative Nameslactyllysine; lactyl-lysine; lysine lactylation; Kla; lactylated lysine
ApplicationWB, ELISA; Recommended dilution: WB, 1:500 - 1:1000; ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
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