BackgroundCatalyzes O-GlcNAcylation of proteins, adding N-acetylglucosamine to serine/threonine residues. Influences insulin signaling, glycolysis, transcription, and circadian rhythm. Modulates chromatin structure via histone modifications. Impacts glucose homeostasis and circadian gene expression by stabilizing clock proteins and promoting clock gene transcription.
DescriptionOGT Recombinant Monoclonal Antibody [8G7]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse, Rat
IsotypeRabbit IgG
Uniprot IDO15294
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human OGT / O-Linked N-Acetylglucosamine Transferase
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT), OGT
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200