BackgroundThe encoded protein from this gene functions as a nuclear transcription factor, binding DNA as a homodimer. It governs the expression of multiple genes, including hepatocyte nuclear factor 1 alpha, a regulator of hepatic gene expression. This gene could play a role in the development of the liver, kidney, and intestines. Mutations in this gene are associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Numerous transcript variants, encoding various isoforms, result from alternative splicing of this gene.
DescriptionHNF4A Recombinant Monoclonal Antibody [10A7]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Rat
IsotypeRabbit IgG
Uniprot IDP41235
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human HNF4A
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesHepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4), HNF4A, HNF4 NR2A1 TCF14
ApplicationELISA, WB, IHC, IF, FC; Recommended dilution: WB:1:500-1:2000, IHC:1:50-1:200, IF:1:50-1:200, FC:1:50-1:200