Histone Phosphorylation Antibodies

Antibodies that detect phosphorylated target proteins help researchers to understand the role phosphorylation plays in cellular processes. Phosphorylation can turn numerous protein enzymes on and off by adding a phosphate group to the proteins, thereby affecting their activity and function.

Histone Phosphorylation

Histone phosphorylation is a post-translational modification that occurs on the tail regions of histone proteins. It entails the addition of a phosphate group to specific amino acid residues on the histone tails, which can affect the structure and function of chromatin. The phosphorylation of histones can modulate the accessibility of DNA to the transcriptional machinery, and thus is involved in regulating gene expression. Histone phosphorylation is mediated by specific enzymes called histone kinases, and is reversible, meaning the phosphate group can be removed by histone phosphatases. This dynamic regulation of histone phosphorylation is thought to play an important role in the cell cycle, DNA damage repair, and other processes.