BackgroundHistone H3 along with H2A, H2B and H4 is involved in the structure of chromatin in eukaryotic cells. Histone H3 can undergo several different types of epigenetic modifications that influence cellular processes. These modifications, including acetylation, phosphorylation, methylation, ubiquitination, and ADP-ribosylation, occur on the N-terminal tail domains of histone H3, which results in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes. In most species, histone H3 is primarily acetylated at lysine 9, 14, 18, and 23.
DescriptionHistone H3K23ac (Acetyl H3K23) Polyclonal Antibody. Unconjugated. Raised in: Rabbit
Uniprot IDP68431, Q71DI3, P84243
PurificationAffinity Purified
SpecificityHuman, Mouse, Rat
IsotypeIgG
Immunogen Synthesized peptide derived from human Histone H3 around the acetylation site of K23.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
StorageShipped at 4°C. Store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Application WB: 1/500 - 1/2000 IF: 1/200 - 1/1000ELISA: 1/5000
Alternative NamesH3K23ac antibody, H3K23a antibody
VCU0006
