Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
DKK2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Liquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.
Protein G purified
Recombinant Human Dickkopf-related protein 2 protein (34-259AA)
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Dickkopf-2, Dkk-2, hDkk-2, DKK2, UNQ682/PRO1316
ELISA, WB, IHC; Recommended dilution: IHC:1:500-1:1000