BackgroundAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
DescriptionDKK1 Recombinant Monoclonal Antibody [1D12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDO94907
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human DKK1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesDickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000