BackgroundRegulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
DescriptionDBF4 Recombinant Monoclonal Antibody [24D8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ9UBU7
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human DBF4
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesProtein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1), DBF4, ASK DBF4A ZDBF1
ApplicationELISA, WB, IF; Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200
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