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CHD1 Polyclonal Antibody

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Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100
Chromatin Immunoprecipitation Hela (1.1*106) were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4ug anti-CDH1 or a control normal rabbit IgG . The resulting ChIP DNA was quantified using real-time PCR with primers against the RPL30 promoter.
Application: ELISA, IHC
Areas of Research: Chromatin Remodeling
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
100% Guarantee: 6 months
Catalog No.SizePriceQty
A68314-05050 µl $199.00 
A68314-100100 µl $299.00 
Availability: Usually Ships Within 1-2 Weeks 
Product Overview

Background
ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.

Description
CHD1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Specificity
Human

Isotype
IgG

Uniprot ID
O14646

Purification
Affinity purified

Immunogen
Recombinant Human Chromodomain-helicase-DNA-binding protein 1 protein (1501-1710AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
CHD-1, ATP-dependent helicase CHD1, CHD1

Application
ELISA, IHC; Recommended dilution: IHC:1:20-1:200

User Guide & MSDS

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