BackgroundPlasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity).
DescriptionCDC42 Recombinant Monoclonal Antibody [3C3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse
IsotypeRabbit IgG
Uniprot IDP60953
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human CDC42
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCell division control protein 42 homolog (G25K GTP-binding protein), CDC42
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
Cart (0)
