This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
BCL2L2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human BCL2L2 (NP_001186768.1).
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
BCL2L2; BCL-W; BCL2-L-2; BCLW; PPP1R51; BCL2 like 2
WB, IHC; Recommended dilution: WB 1:500 - 1:2000, IHC 1:50 - 1:100