BackgroundResponsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
DescriptionBACE1 Recombinant Monoclonal Antibody [7G3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Mouse, Rat
IsotypeRabbit IgG
Uniprot IDP56817
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human BACE1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesBeta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2), BACE1, BACE KIAA1149
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000