This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.
ACTL6A Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recombinant Protein of Human ACTL6A
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Arp4, ACTL6, BAF53A, INO80K, ARPN-BETA
WB; Recommended dilution: WB 1:500 - 1:2000