TINF2 Recombinant Monoclonal Antibody [5G11]

Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

Description
TINF2 Recombinant Monoclonal Antibody [5G11]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human, Mouse, Rat

Isotype
Rabbit IgG

Uniprot ID
Q9BSI4

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human Tin2

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2), TINF2, TIN2

Application
ELISA, WB; Recommended dilution: WB:1:500-1:5000