BackgroundThis gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants.
DescriptionSDHD Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDO14521
PurificationAffinity Purification
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 50-150 of human SDHD (NP_002993.1).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesSDHD; CBT1; CII-4; CWS3; PGL; PGL1; QPs3; SDH4; cybS; succinate dehydrogenase complex subunit D
ApplicationWB; Recommended dilution: WB: 1:500-1:2000