BackgroundPre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.
DescriptionPRPF8 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDQ6P2Q9
PurificationAffinity Purification
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRPF8 (NP_006436.3).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesPRPF8; HPRP8; PRP8; PRPC8; RP13; SNRNP220; pre-mRNA processing factor 8
ApplicationWB, IHC, IF, IP; Recommended dilution: WB 1:500 - 1:1000, IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:50 - 1:100