BackgroundActs downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73.
DescriptionPhospho-PTPN11 (Y542) Recombinant Monoclonal Antibody [2E2]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ06124
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-PTPN11 (Y542)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesTyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2
ApplicationELISA, WB, IP; Recommended dilution: WB:1:500-1:5000, IP:1:200-1:1000