BackgroundTumor suppressor with dual-specificity phosphatase activity. Dephosphorylates tyrosine, serine, and threonine residues. Also acts as a lipid phosphatase, opposing PI3K-AKT/PKB signaling by dephosphorylating phosphoinositides. Inhibits cell migration, modulates cell cycle and survival. Regulates AKT-mTOR pathway, aiding neuron integration in neurogenesis. Impacts insulin signaling and glucose metabolism. Monoubiquitination enhances apoptosis, while nonubiquitinated form has tumor suppressive ability. Shapes cell movement and polarization.
DescriptionPhospho-PTEN (S380) Recombinant Monoclonal Antibody [4D10]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP60484
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-PTEN (S380)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesPhosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000
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