BackgroundProtein kinase C (PKC) is a group of serine- and threonine-specific protein kinases activated by calcium and diacylglycerol, a second messenger. PKC members phosphorylate various proteins, participating in diverse cellular signaling pathways. They are key receptors for tumor-promoting phorbol esters. Each PKC member has a distinct expression profile and specific roles in cells. This gene encodes one PKC family member, implicated in processes like cell adhesion, transformation, cell cycle control, and volume regulation. Mouse knockout studies suggest its crucial role in regulating cardiac contractility and Ca(2+) handling in myocytes.
DescriptionPhospho-PRKCA (T638) Recombinant Monoclonal Antibody [3A5]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP17252
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-PRKCA (T638)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesProtein kinase C alpha type, PKC-A, PKC-alpha, PRKCA, PKCA, PRKACA
ApplicationELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200