BackgroundMutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
DescriptionPhospho NBN (S343) Recombinant Monoclonal Antibody [1B4]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDO60934
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-NBN (S343)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesNibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, NBN, NBS, NBS1, P95
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000
Cart (0)
