Phospho-ACLY-S455 Polyclonal Antibody

Background
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Description
Phospho-ACLY-S455 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.

Specificity
Mouse, Rat

Isotype
IgG

Uniprot ID
P53396

Purification
Affinity Purified

Immunogen
A synthetic phosphorylated peptide around S455 of human ACLY (NP_001087.2).

Storage
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Alternative Names
ACLY; ACL; ATPCL; CLATP; ATP citrate lyase

Application
WB, IHC, IP; Recommended dilution: WB: 1:500-1:2000, IHC: 1:50-1:100, IP:1:50-1:100