BackgroundThis gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
DescriptionNAIP Recombinant Monoclonal Antibody [13E6]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ13075
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human NAIP
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesBaculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein), NAIP, BIRC1
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200