MYLK Recombinant Monoclonal Antibody [28C5]

Background
Calcium/calmodulin-dependent myosin light chain kinase is vital for smooth muscle contraction by phosphorylating myosin light chains (MLC) and regulating actin-myosin interaction. It influences inflammation, cell motility, airway hyperreactivity, and asthma-related activities. Required for airway and gastrointestinal muscle contraction, cell survival, wound healing, and migration. Also involved in various signaling pathways and membrane localization. Critical for fibroblast apoptosis, tight junction regulation, and mediating barrier injuries. Important in cellular responses to infections and cancer proliferation.

Description
MYLK Recombinant Monoclonal Antibody [28C5]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
Rabbit IgG

Uniprot ID
Q15746

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human MYLK

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form], MYLK, MLCK MLCK1 MYLK1

Application
ELISA, WB, FC; Recommended dilution: WB:1:500-1:2000, FC:1:50-1:200