BackgroundActs as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
DescriptionKeap1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Formulation0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDQ9Z2X8
PurificationProtein G purified
ImmunogenRecombinant Mouse Kelch-like ECH-associated protein 1 protein (1-624AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesKelch-like ECH-associated protein 1, Keap1, Inrf2, Kiaa0132, Cytosolic inhibitor of Nrf2, INrf2
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:2000