BackgroundInhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
DescriptionIL1RN Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDP18510
Purification>95%, Protein G purified
ImmunogenRecombinant Human Interleukin-1 receptor antagonist protein (26-177AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesICIL-1RA, IL1 inhibitor, INN=Anakinra IL1RN, IL1F3, IL1RA
ApplicationELISA, WB; Recommended dilution: WB:1:1000-1:5000