BackgroundCatalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection.
DescriptionHM13 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDQ8TCT9
Purification>95%, Protein G purified
ImmunogenRecombinant Human Minor histocompatibility antigen H13 protein (336-377AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesMinor histocompatibility antigen H13 (EC:3.4.23.-), HM13, H13, IMP1, PSL3, SPP, MSTP086, Intramembrane protease 1, IMP-1, IMPAS-1, hIMP1, Presenilin-like protein 3, Signal peptide peptidase
ApplicationELISA, WB, IF; Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200