BackgroundInvolved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.
DescriptionFIS1 Recombinant Monoclonal Antibody [27B4]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ9Y3D6
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human FIS1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMitochondrial fission 1 protein (FIS1 homolog) (hFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11), FIS1, TTC11
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:50-1:200