BackgroundMay play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
DescriptionFcmr Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.
SpecificityMouse, Rat
IsotypeIgG
Uniprot IDA1KXC4
Purification>95%, Protein G purified
ImmunogenRecombinant Mouse Fas apoptotic inhibitory molecule 3 protein (18-262AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative NamesRegulator of Fas-induced apoptosis Toso, Faim3, Toso
ApplicationELISA, WB; Recommended dilution: WB:1:1000-1:5000