Epigenetic regulation involves a fine-tuned balance of enzymatic activity—histone modifications like methylation and acetylation are dynamic and reversible processes controlled by specific writer and eraser enzymes. EpigenTek provides a complete set of tools to accurately measure the activity and inhibition of key epigenetic enzymes, helping researchers decipher their roles in gene regulation, chromatin dynamics, and disease development.
Our histone extraction kits offer fast, reliable isolation of total core histones from mammalian cells or tissues, with intact PTMs—ideal for use in EpigenTek’s histone modification assays or other downstream applications such as methylation, acetylation, phosphorylation, and more.
Our nuclear extraction kit enables fast, efficient isolation of high-quality nuclear proteins from cells or tissues while preserving enzymatic activity—ideal for use in our histone modification assays and a wide range of downstream applications.
Explore Our Powerful Solutions for In Vivo Protein-DNA Interactions
Histone Methyltransferase (HMT) Assays: Histone methyltransferases catalyze the methylation of lysine, arginine, and other residues on histone proteins. These methylation marks influence chromatin structure and gene expression patterns. Aberrant HMT activity is implicated in cancer, neurological disorders, and more, making them prime drug targets.
Histone Demethylase (HDM) Assays:
Histone demethylases dynamically remove methyl groups from histones, reversing previously thought irreversible epigenetic marks. Studying HDMs is essential for understanding gene reprogramming and pathological states like cancer.
Histone Acetyltransferase (HAT) Assay:
Histone acetyltransferases are enzymes that transfer acetyl groups from acetyl-coenzyme A to the lysine residues of histones. These enzymes play important roles in regulating gene expression by modifying the structure of chromatin, making it more accessible for transcription.
Histone Deacetylase (HDAC) Assays: HDACs remove acetyl groups from histones, promoting chromatin condensation and gene repression. Their dysregulation is associated with cancer, neurodegeneration, and metabolic diseases. HDAC inhibitors are an important class of therapeutic drugs under active investigation.
*10% Off Promotion: Applies only to Chromatin Immunoprecipitation (ChIP) kits with code E2501CHR. Excludes Chromatin Extraction Kits. Orders must include the code to receive the discount. No retroactive discounts allowed. Offer valid for U.S. customers only. Not available to distributors or resellers. Cannot be combined with other offers. Expires March 31, 2025.
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