BackgroundThe protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
DescriptionEif2ak2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP19525
PurificationAffinity Purified
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human Eif2ak2 (NP_002750.1)
StorageShipped at 4°C. Store at -20°C. Avoid freeze / thaw cycles.
Alternative NamesEIF2AK1; PKR; PPP1R83; PRKR; Eif2ak2; EIF2AK2
ApplicationWB, IHC, IF; Recommended dilution: WB 1:500 - 1:2000, IHC 1:100 - 1:200, IF 1:50 - 1:200