BackgroundThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
DescriptionCAV1 Recombinant Monoclonal Antibody [2A7]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDQ03135
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from Human CAV1
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCaveolin-1, CAV1, CAV
ApplicationELISA, WB, FC; Recommended dilution: WB:1:500-1:2000, FC:1:50-1:200