Caspase-3 Monoclonal Antibody

Background
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

Description
Caspase-3 Monoclonal Antibody. Unconjugated. Raised in: Mouse.

Formulation
Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH7.3.

Specificity
Human, Mouse

Isotype
IgG1, Kappa

Uniprot ID
P42574

Purification
Affinity Purified

Immunogen
Recombinant protein (or fragment). Please contact EpigenTek for more information.

Storage
Store at -20°C. Avoid freeze / thaw cycles.

Alternative Names
CPP32; SCA-1; CPP32B; Caspase-3

Application
WB, ELISA; Recommended dilution: WB, 1:500 - 1:2000; ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.