BackgroundC3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.
DescriptionC3 Recombinant Monoclonal Antibody [8C3]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP01024
PurificationAffinity-chromatography
ImmunogenA synthesized peptide derived from human C3 / C3a
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesComplement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain, C3-beta-c (C3bc), Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein (ASP) (C3adesArg), Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2], C3, CPAMD1
ApplicationELISA, IHC; Recommended dilution: IHC:1:50-1:200