C3 Polyclonal Antibody, Biotin Conjugated

Background
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Ref. 5 Ref. 11 Ref. 14 Ref. 15 Ref. 16 Ref. 22 Ref. 25 Ref. 30 Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. Ref. 5 Ref. 11 Ref. 14 Ref. 15 Ref. 16 Ref. 22 Ref. 25 Ref. 30 Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for GPR77. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of GPR77.

Description
C3 Polyclonal Antibody, Biotin Conjugated. Biotin. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human

Isotype
IgG

Uniprot ID
P01024

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Complement C3 protein (26-225AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CPAMD1

Application
ELISA; Recommended dilution: ELISA 1:500-1:1000