This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
ATIC Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ATIC (NP_004035.2).
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
ATIC; AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH; bifunctional purine biosynthesis protein PURH
WB; Recommended dilution: WB 1:500 - 1:2000