Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
SETD2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Human, Mouse, Rat
Recombinant Protein of Human SETD2
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
HYPB, SET2, HIF-1, HIP-1, KMT3A, HBP231, HSPC069, p231HBP
WB, IF; Recommended dilution: WB 1:500-1:2000, IF 1:50-1:200